Reporting data from high-throughput screening of small-molecule libraries

Nat Chem Biol. 2007 Aug;3(8):438-41. doi: 10.1038/nchembio0807-438.


Publications reporting results of small-molecule screens are becoming more common as academic researchers increasingly make use of high-throughput screening (HTS) facilities. However, no standards have been formally established for reporting small-molecule screening data, and often key information important for the evaluation and interpretation of results is omitted in published HTS protocols. Here, we propose concise guidelines for reporting small-molecule HTS data.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, N.I.H., Intramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Chemistry, Pharmaceutical / methods*
  • Combinatorial Chemistry Techniques*
  • Dose-Response Relationship, Drug
  • Drug Design
  • Drug Evaluation, Preclinical
  • Guidelines as Topic
  • Humans
  • Inhibitory Concentration 50
  • Models, Chemical
  • Molecular Conformation
  • Pharmaceutical Preparations
  • Technology, Pharmaceutical / methods*


  • Pharmaceutical Preparations