Scaffold composition and biological relevance of screening libraries

Nat Chem Biol. 2007 Aug;3(8):442-6. doi: 10.1038/nchembio0807-442.


The chemical scaffolds from which screening libraries are built have strong influence on the libraries' utility for screening campaigns. Here we present analysis of the scaffold composition of several types of commercially available screening collections and compare those compositions to those of drugs and drug candidates.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Chemistry, Pharmaceutical / methods
  • Combinatorial Chemistry Techniques
  • Drug Design
  • Drug Evaluation, Preclinical / instrumentation*
  • Drug Evaluation, Preclinical / methods*
  • Ligands
  • Models, Chemical
  • Molecular Conformation
  • Molecular Structure
  • Peptide Library
  • Phenotype
  • Technology, Pharmaceutical / methods


  • Ligands
  • Peptide Library