Innate protection of Mycobacterium smegmatis against the antimicrobial activity of nitric oxide is provided by mycothiol

Antimicrob Agents Chemother. 2007 Sep;51(9):3364-6. doi: 10.1128/AAC.00347-07. Epub 2007 Jul 16.

Abstract

Nitric oxide (NO) is an efficient antimicrobial agent. A role for mycothiol in protecting mycobacteria from nitrosative damage was revealed by showing that a Mycobacterium smegmatis mutant is sensitive to NO. A direct correlation between NO and mycothiol levels confirmed that mycothiol is important for protecting mycobacteria from NO attack.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Bacterial Agents / antagonists & inhibitors*
  • Anti-Bacterial Agents / metabolism
  • Anti-Bacterial Agents / pharmacology*
  • Cysteine / metabolism
  • Cysteine / pharmacology*
  • Drug Resistance, Bacterial / drug effects
  • Drug Resistance, Bacterial / genetics
  • Genes, Bacterial
  • Glycopeptides / metabolism
  • Glycopeptides / pharmacology*
  • Inositol / metabolism
  • Inositol / pharmacology*
  • Mutation
  • Mycobacterium smegmatis / drug effects*
  • Mycobacterium smegmatis / genetics
  • Mycobacterium smegmatis / metabolism
  • Nitric Oxide / antagonists & inhibitors*
  • Nitric Oxide / metabolism
  • Nitric Oxide / pharmacology*

Substances

  • Anti-Bacterial Agents
  • Glycopeptides
  • mycothiol
  • Nitric Oxide
  • Inositol
  • Cysteine