Yttrium 90 microsphere selective internal radiation treatment of hepatic colorectal metastases

Arch Surg. 2007 Jul;142(7):675-82. doi: 10.1001/archsurg.142.7.675.


Objective: To discuss the basic concepts involved in the development of yttrium 90 (Y-90) microsphere selective internal radiation treatment and review the clinical data pertaining to its application in hepatic colorectal cancer metastases.

Data sources: Published studies and scientific paper presentations.

Study selection: Randomized clinical studies and retrospective reviews.

Conclusions: Selective internal radiation treatment is a promising new modality in the treatment of patients with hepatic colorectal cancer metastases as part of a multimodality approach. A chemo-selective internal radiation treatment neoadjuvant approach has a potential to improve therapeutic outcomes. Clinical studies in neoadjuvant and salvage settings are needed for more concrete outcome data and design of optimal multimodality treatment strategies.

Publication types

  • Review

MeSH terms

  • Brachytherapy / methods*
  • Colonic Neoplasms / pathology*
  • Humans
  • Liver Neoplasms / radiotherapy
  • Liver Neoplasms / secondary*
  • Microspheres
  • Neoadjuvant Therapy
  • Radiopharmaceuticals / therapeutic use*
  • Randomized Controlled Trials as Topic
  • Rectal Neoplasms / pathology*
  • Retrospective Studies
  • Treatment Outcome
  • Yttrium Radioisotopes / therapeutic use*


  • Radiopharmaceuticals
  • Yttrium Radioisotopes