Rapid synthesis of iminosugar derivatives for cell-based in situ screening: discovery of "hit" compounds with anticancer activity

ChemMedChem. 2007 Nov;2(11):1594-7. doi: 10.1002/cmdc.200700120.

Abstract

Effective and efficacious drug screening methods are imperative in the drug discovery process. A library has been constructed efficiently and followed by in situ cell‐based screening without product purification. This method led to discovery of several iminosugar derivatives with anticancer activity.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Agents / pharmacology*
  • Carbohydrate Conformation
  • Cell Line, Tumor
  • Drug Screening Assays, Antitumor
  • Humans
  • Imino Sugars / chemical synthesis*
  • Imino Sugars / pharmacology

Substances

  • Antineoplastic Agents
  • Imino Sugars