Rhinitis symptoms and quality of life in patients with chronic perennial rhinitis treated with desloratadine

J Laryngol Otol. 2007 Dec;121(12):1151-5. doi: 10.1017/S0022215107000059. Epub 2007 Jul 19.


Objective: To evaluate the outcome and the change in quality of life of patients with chronic rhinitis after treatment with desloratadine.

Study design: A prospective, open-label, non-blinded, non-randomised study of patients in a secondary and tertiary ENT referral centre.

Methods: Chinese patients with chronic rhinitis were recruited. The patients were assessed by a questionnaire that included rhinitis symptoms score and SF-36 health survey components. Endoscopic assessment was performed with a rigid nasoendoscope and scored according to the modified endoscopic appearance score of Lund and Kennedy. A 12-week course of desloratadine 5 mg daily was prescribed. Patients were re-evaluated after treatment. A total of 47 subjects completed the study.

Results: There were significant reductions in median rhinitis symptoms score, from six to five (p < 0.001), and in median endoscopic appearance score, from five to three (p < 0.001). Patients' general health perception was also improved after treatment (p == 0.022).

Conclusion: Desloratadine may be an effective treatment which provides symptomatic relief and improves the quality of life in patients with chronic rhinitis.

Publication types

  • Clinical Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Chronic Disease
  • Endoscopy
  • Female
  • Histamine H1 Antagonists, Non-Sedating / therapeutic use*
  • Humans
  • Loratadine / analogs & derivatives*
  • Loratadine / therapeutic use
  • Male
  • Middle Aged
  • Prospective Studies
  • Quality of Life*
  • Rhinitis, Allergic, Perennial / drug therapy*
  • Severity of Illness Index
  • Treatment Outcome


  • Histamine H1 Antagonists, Non-Sedating
  • Loratadine
  • desloratadine