A whole-genome association study of major determinants for host control of HIV-1

Science. 2007 Aug 17;317(5840):944-7. doi: 10.1126/science.1143767. Epub 2007 Jul 19.

Abstract

Understanding why some people establish and maintain effective control of HIV-1 and others do not is a priority in the effort to develop new treatments for HIV/AIDS. Using a whole-genome association strategy, we identified polymorphisms that explain nearly 15% of the variation among individuals in viral load during the asymptomatic set-point period of infection. One of these is found within an endogenous retroviral element and is associated with major histocompatibility allele human leukocyte antigen (HLA)-B*5701, whereas a second is located near the HLA-C gene. An additional analysis of the time to HIV disease progression implicated two genes, one of which encodes an RNA polymerase I subunit. These findings emphasize the importance of studying human genetic variation as a guide to combating infectious agents.

Publication types

  • Multicenter Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cohort Studies
  • DNA-Binding Proteins / genetics
  • Disease Progression
  • Female
  • Genes, MHC Class I
  • Genome, Human*
  • HIV Infections / genetics*
  • HIV Infections / immunology
  • HIV Infections / therapy
  • HIV Infections / virology*
  • HIV-1 / physiology*
  • HLA-B Antigens / genetics*
  • HLA-C Antigens / genetics*
  • Haplotypes
  • Humans
  • Immediate-Early Proteins / genetics
  • Major Histocompatibility Complex / genetics*
  • Male
  • Polymorphism, Single Nucleotide
  • RNA, Long Noncoding
  • RNA, Untranslated
  • Regression Analysis
  • Viral Load

Substances

  • DNA-Binding Proteins
  • HCP5 long noncoding RNA, human
  • HLA-B Antigens
  • HLA-B*57:01 antigen
  • HLA-C Antigens
  • Immediate-Early Proteins
  • RNA, Long Noncoding
  • RNA, Untranslated
  • RNF39 protein, human
  • ZNRD1 protein, human