The homeodomain LIM protein Isl-1 is expressed in subsets of neurons and endocrine cells in the adult rat

Neuron. 1991 Dec;7(6):881-9. doi: 10.1016/0896-6273(91)90334-v.


We have used immunocytochemical methods to localize the homeodomain LIM protein Isl-1 in the adult rat. Isl-1 immunoreactivity is expressed in polypeptide hormone-producing cells of the endocrine system, in neurons of the peripheral nervous system, and in a subset of brain nuclei. Isl-1 is also expressed in a subset of motoneurons in the spinal cord and brain stem, but not in regions of the central nervous system involved in sensory function or in neocortical areas. The pattern of expression of Isl-1 suggests that this gene may be involved in the specification and maintenance of differentiated phenotypical properties of these cells.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • DNA-Binding Proteins / analysis*
  • DNA-Binding Proteins / genetics
  • Endocrine Glands / cytology
  • Endocrine Glands / physiology*
  • Gene Expression
  • Homeodomain Proteins*
  • Immune Sera / isolation & purification
  • Immunohistochemistry
  • Islets of Langerhans / cytology
  • Islets of Langerhans / physiology
  • LIM-Homeodomain Proteins
  • Motor Neurons / cytology
  • Motor Neurons / physiology
  • Nerve Tissue Proteins*
  • Neurons / cytology
  • Neurons / physiology*
  • Organ Specificity
  • Phenotype
  • Pituitary Gland, Anterior / cytology
  • Pituitary Gland, Anterior / physiology
  • RNA, Messenger / analysis
  • RNA, Messenger / genetics
  • Rats
  • Rats, Inbred Strains
  • Thyroid Gland / cytology
  • Thyroid Gland / physiology
  • Transcription Factors


  • DNA-Binding Proteins
  • Homeodomain Proteins
  • Immune Sera
  • LIM-Homeodomain Proteins
  • Nerve Tissue Proteins
  • RNA, Messenger
  • Transcription Factors
  • insulin gene enhancer binding protein Isl-1