PASS-predicted design, synthesis and biological evaluation of cyclic nitrones as nootropics

Bioorg Med Chem Lett. 2007 Sep 15;17(18):5251-5. doi: 10.1016/j.bmcl.2007.06.071. Epub 2007 Jun 30.


Out of 400 virtually designed imidazoline N-oxides, five cyclic nitrones were selected on the basis of PASS prediction as potent nootropics and were evaluated for their biological activities in albino mice. The selected N-alkyl and aryl-substituted nitrones were found to be excellent nootropics. A series of lead compounds acting as cognition enhancers have been provided, which can be further exploited in search of such New Chemical Entities (NCEs).

MeSH terms

  • Animals
  • Behavior, Animal
  • Drug Design*
  • Maze Learning / drug effects
  • Memory / drug effects
  • Mice
  • Nitrogen Oxides / chemical synthesis*
  • Nitrogen Oxides / chemistry
  • Nitrogen Oxides / pharmacology*
  • Nootropic Agents / chemical synthesis*
  • Nootropic Agents / chemistry
  • Nootropic Agents / pharmacology*


  • Nitrogen Oxides
  • Nootropic Agents
  • nitrones