Breast screening, prognostic factors and survival--results from the Swedish two county study

Br J Cancer. 1991 Dec;64(6):1133-8. doi: 10.1038/bjc.1991.477.


The results of the Swedish two-county study are analysed with respect to tumour size, nodal status and malignancy grade, and the relationship of these prognostic factors to screening and to survival. It is shown that these factors can account for much of the differences in survival between incidence screen detected, interval and control group cancers but to a lesser extent for cancers detected at the prevalence screen where length bias is greatest. Furthermore, examination of the relationships among the prognostic factors and mode of detection indicates that malignancy grade, as a measure of inherent malignant capacity, evolves as a tumour grows. The proportion of cancers with poor malignancy grade is several fold lower for cancers of diameter less than 15 cm than for cancers greater than 30 cm, independent of the length bias of screening. The implications of these findings for screening frequency are briefly discussed.

MeSH terms

  • Adult
  • Age Factors
  • Breast Neoplasms / diagnosis*
  • Breast Neoplasms / epidemiology
  • Breast Neoplasms / pathology
  • Humans
  • Lymphatic Metastasis
  • Mammography
  • Mass Screening
  • Middle Aged
  • Prognosis
  • Regression Analysis
  • Survival Analysis
  • Time Factors