Yersinia pestis CO92 delta yopH is a potent live, attenuated plague vaccine

Sarah S Bubeck; Peter H Dube

doi:10.1128/CVI.00137-07

Yersinia pestis CO92 delta yopH is a potent live, attenuated plague vaccine

Clin Vaccine Immunol. 2007 Sep;14(9):1235-8. doi: 10.1128/CVI.00137-07. Epub 2007 Jul 25.

Authors

Sarah S Bubeck¹, Peter H Dube

Affiliation

¹ Department of Microbiology and Immunology, The University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Dr., San Antonio, TX 78229, USA.

Abstract

An in-frame deletion of the yopH gene in Yersinia pestis CO92 attenuates virulence in both bubonic and pneumonic plague models. When it is used as a live, attenuated vaccine, CO92 delta yopH provides a high degree of protection from parental and respiratory challenge with Y. pestis CO92.

MeSH terms

Animals
Bacterial Outer Membrane Proteins / immunology*
Bacterial Outer Membrane Proteins / metabolism
Female
Mice
Plague / microbiology
Plague / prevention & control*
Plague Vaccine / immunology*
Plague Vaccine / pharmacology
Protein Tyrosine Phosphatases / immunology*
Protein Tyrosine Phosphatases / metabolism
Vaccines, Attenuated / immunology
Vaccines, Attenuated / pharmacology
Yersinia pestis / immunology*

Substances

Bacterial Outer Membrane Proteins
Plague Vaccine
Vaccines, Attenuated
Protein Tyrosine Phosphatases
yopH protein, Yersinia