In all, 20 eyes of 20 normal-tension glaucoma (NTG) patients and 20 eyes of high-tension glaucoma (HTG) patients matched for similar visual field defects underwent retinal nerve-fiber-layer (RNFL) analysis using a computerized digital-image analysis system. Subjects with NTG showed more localized RNFL loss than diffuse loss as compared with HTG patients. The results support the hypothesis that there may be different mechanisms of damage in glaucoma.