Innate pathogen recognition in the kidney: toll-like receptors, NOD-like receptors, and RIG-like helicases

Kidney Int. 2007 Nov;72(9):1051-6. doi: 10.1038/sj.ki.5002436. Epub 2007 Jul 25.

Abstract

How do infections trigger or aggravate renal pathology? The discovery of the toll-like receptors, and more recently, the retinoic-acid-inducible protein-like helicases and the nucleotide-binding oligomerization domain-like receptors may offer new concepts to answer this question. Common pathogen-associated molecules are recognized by these receptors in several cellular compartments of immune cells and non-immune cells inside the kidney. This article summarizes ligand-receptor interactions and their known or potential significance in kidney diseases.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Humans
  • Immunity, Innate / physiology*
  • Kidney Diseases / immunology*
  • Kidney Diseases / physiopathology
  • Nod Signaling Adaptor Proteins / physiology
  • RNA Helicases / physiology
  • Toll-Like Receptors / physiology

Substances

  • Nod Signaling Adaptor Proteins
  • Toll-Like Receptors
  • RNA Helicases