Chiral amines as organocatalysts for asymmetric conjugate addition to nitroolefins and vinyl sulfones via enamine activation

Chem Commun (Camb). 2007 Aug 14:(30):3123-35. doi: 10.1039/b701216k. Epub 2007 Mar 21.


Over the last decade the potential of organocatalysis has successfully been demonstrated. In particular, chiral amines such as pyrrolidine analogues have emerged as a broadly applicable class of organocatalyst for asymmetric conjugate addition via enamine activation. This Feature Article documents the development of these catalysts, emphasizing the design and mechanistic features that supply high selectivity in asymmetric Michael reactions.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Alkenes / chemistry*
  • Amines / chemistry*
  • Catalysis
  • Nitro Compounds / chemistry*
  • Pyrrolidines / chemical synthesis*
  • Pyrrolidines / chemistry
  • Stereoisomerism
  • Sulfones / chemistry*
  • Vinyl Compounds / chemistry*


  • Alkenes
  • Amines
  • Nitro Compounds
  • Pyrrolidines
  • Sulfones
  • Vinyl Compounds