Novel gcm-dependent lineages in the postembryonic nervous system of Drosophila melanogaster

Dev Dyn. 2007 Aug;236(8):2101-8. doi: 10.1002/dvdy.21232.


glial cells missing genes (gcm and gcm2) act as the glial fate determinants in the Drosophila embryo. However, their requirement in the adult central nervous system (CNS) is at present not known, except for their role in lamina glia. This is particularly important with respect to two recent sets of data. Adult glial subpopulations differentiate through embryonic glia proliferation. Also, gcm-gcm2 are required for the differentiation of specific adult neurons. We here show that gcm is expressed in precursors and postmitotic, migrating, cells of the medulla neuropile glia (mng) lineage. It is also expressed in a thoracic glial lineage and in neurons of the ventral nerve cord (VNC). Finally, while gcm is required for gliogenesis in medulla and VNC, it does not seem to be required for the generation of VNC neurons.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cell Differentiation
  • Cell Lineage
  • Cell Proliferation
  • DNA-Binding Proteins / physiology*
  • Dihydropyridines*
  • Drosophila Proteins / physiology*
  • Drosophila melanogaster
  • Nerve Tissue Proteins / physiology
  • Nervous System / cytology*
  • Nervous System / growth & development
  • Neuroglia / cytology*
  • Neurons / cytology*
  • Transcription Factors / physiology*


  • DNA-Binding Proteins
  • Dihydropyridines
  • Drosophila Proteins
  • GCM protein, Drosophila
  • Gcm2 protein, Drosophila
  • Nerve Tissue Proteins
  • Transcription Factors
  • F 0401