Aptamers and small molecules play tug of war

Chem Biol. 2007 Jul;14(7):736-8. doi: 10.1016/j.chembiol.2007.07.003.

Abstract

Recently, aptamers began to emerge as therapeutics. In this issue of Chemistry & Biology, Famulok and colleagues [1] present a twist on this concept, using an enzyme-inhibiting aptamer as a tool to screen for small molecules that block HIV replication.

Publication types

  • Comment

MeSH terms

  • Aptamers, Nucleotide / chemistry*
  • Fluorescence Resonance Energy Transfer
  • HIV / drug effects
  • HIV / physiology
  • Reverse Transcriptase Inhibitors / pharmacology
  • Virus Replication / drug effects

Substances

  • Aptamers, Nucleotide
  • Reverse Transcriptase Inhibitors