Vascular endothelial growth factor receptor-2: structure, function, intracellular signalling and therapeutic inhibition

Cell Signal. 2007 Oct;19(10):2003-12. doi: 10.1016/j.cellsig.2007.05.013. Epub 2007 Jun 12.


Vascular endothelial growth factors (VEGFs) regulate vascular development, angiogenesis and lymphangiogenesis by binding to a number of receptors. VEGFR-1 is required for the recruitment of haematopoietic stem cells and the migration of monocytes and macrophages, VEGFR-2 regulates vascular endothelial function and VEGFR-3 regulates lymphatic endothelial cell function. Over the last decade, considerable progress has been made in delineating the VEGFR-2 specific intracellular signalling cascades leading to proliferation, migration, survival and increased permeability, each of which contributes to the angiogenic response. Furthermore, therapeutic inhibition of VEGFR-2 action is now having an impact in the clinic for the treatment of a number of diseases.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Gene Expression Regulation
  • Humans
  • Neoplasms / drug therapy
  • Signal Transduction*
  • Vascular Endothelial Growth Factor Receptor-2 / antagonists & inhibitors
  • Vascular Endothelial Growth Factor Receptor-2 / chemistry*
  • Vascular Endothelial Growth Factor Receptor-2 / physiology*
  • Vascular Endothelial Growth Factors / genetics
  • Vascular Endothelial Growth Factors / metabolism


  • Vascular Endothelial Growth Factors
  • Vascular Endothelial Growth Factor Receptor-2