Comparison of frozen and freeze-dried particulate bone allografts

Theodore Malinin; H Thomas Temple

doi:10.1016/j.cryobiol.2007.05.007

Comparison of frozen and freeze-dried particulate bone allografts

Cryobiology. 2007 Oct;55(2):167-70. doi: 10.1016/j.cryobiol.2007.05.007. Epub 2007 Jun 15.

Authors

Theodore Malinin¹, H Thomas Temple

Affiliation

¹ Tissue Bank, Department of Orthopaedics (R-12), University of Miami, Miller School of Medicine, Miami, FL 33101, USA. tmalinin@med.miami.edu

PMID: 17658506
DOI: 10.1016/j.cryobiol.2007.05.007

Abstract

Freeze-dried and frozen particulate bone allografts are used interchangeably on the assumption that the biologic behavior of these grafts is similar. Dissimilarities in biologic behavior and differences in the rate and extent of bone incorporation of freeze-dried and frozen particulate grafts were demonstrated in a comparative study using a non-human primate model. Freeze-dried particulate allografts induced new bone formation and healing of the osseous defects much faster than the frozen allografts.

Publication types

Comparative Study
Research Support, Non-U.S. Gov't

MeSH terms

Animals
Bone Transplantation*
Cryopreservation / methods*
Papio hamadryas
Tibia / transplantation*
Transplantation, Homologous
Transplants