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Review
, 25 (3), 611-67, v

Genetics of Alzheimer's Disease: A Centennial Review

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Review

Genetics of Alzheimer's Disease: A Centennial Review

Nilüfer Ertekin-Taner. Neurol Clin.

Abstract

Alzheimer's disease (AD) genetics may be one of the most prolifically published areas in medicine and biology. Three early-onset AD genes with causative mutations (APP, PSEN1, PSEN2) and one late-onset AD susceptibility gene, apolipoprotein E (APOE), exist with ample biologic, genetic, and epidemiologic data. Evidence suggests a significant genetic component underlying AD that is not explained by the known genetic risk factors. This article summarizes the evidence for the genetic component in AD and the identification of the early-onset familial AD genes and APOE, and examines the current state of knowledge about additional AD susceptibility loci and alleles. The future directions for genetic research in AD as a common and complex condition are also discussed.

Figures

FIGURE 1
FIGURE 1
FIGURE 1A–E. Chromosomal map summaries of whole genome linkage and association studies in AD. The plain karyotype figures were taken from the Ensemble website (http://www.ensembl.org/info/software/website/installation/build.html). The markers’ chromosomal locations were determined according to the March 2006 assembly on the UCSC Genome Browser (http://genome.ucsc.edu/). Chromosomes 16, 17, 21 and 22 are not shown since there is only a single suggestive/significant result from a single study for these chromosomes.
FIGURE 1
FIGURE 1
FIGURE 1A–E. Chromosomal map summaries of whole genome linkage and association studies in AD. The plain karyotype figures were taken from the Ensemble website (http://www.ensembl.org/info/software/website/installation/build.html). The markers’ chromosomal locations were determined according to the March 2006 assembly on the UCSC Genome Browser (http://genome.ucsc.edu/). Chromosomes 16, 17, 21 and 22 are not shown since there is only a single suggestive/significant result from a single study for these chromosomes.
FIGURE 1
FIGURE 1
FIGURE 1A–E. Chromosomal map summaries of whole genome linkage and association studies in AD. The plain karyotype figures were taken from the Ensemble website (http://www.ensembl.org/info/software/website/installation/build.html). The markers’ chromosomal locations were determined according to the March 2006 assembly on the UCSC Genome Browser (http://genome.ucsc.edu/). Chromosomes 16, 17, 21 and 22 are not shown since there is only a single suggestive/significant result from a single study for these chromosomes.
FIGURE 1
FIGURE 1
FIGURE 1A–E. Chromosomal map summaries of whole genome linkage and association studies in AD. The plain karyotype figures were taken from the Ensemble website (http://www.ensembl.org/info/software/website/installation/build.html). The markers’ chromosomal locations were determined according to the March 2006 assembly on the UCSC Genome Browser (http://genome.ucsc.edu/). Chromosomes 16, 17, 21 and 22 are not shown since there is only a single suggestive/significant result from a single study for these chromosomes.

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