The potential impact of the preparation rich in growth factors (PRGF) in different medical fields

Biomaterials. 2007 Nov;28(31):4551-60. doi: 10.1016/j.biomaterials.2007.06.037. Epub 2007 Jul 30.


Platelet-rich preparations constitute a relatively new biotechnology for the stimulation and acceleration of tissue healing and bone regeneration. The versatility and biocompatibility of this approach has stimulated its therapeutic use in numerous medical and scientific fields including dentistry, oral implantology, orthopaedics, ulcer treatment, tissue engineering among others. Here we discuss the important progress that has been accomplished in the field of platelet-rich preparations in the last few years. Some of the most interesting therapeutic applications of this technology are discussed as are some of the limitations, future challenges and directions in the field.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Biocompatible Materials / chemistry*
  • Feasibility Studies
  • Intercellular Signaling Peptides and Proteins / chemistry*
  • Intercellular Signaling Peptides and Proteins / metabolism*
  • Platelet-Derived Growth Factor / chemistry
  • Platelet-Derived Growth Factor / metabolism
  • Tissue Engineering / methods*


  • Biocompatible Materials
  • Intercellular Signaling Peptides and Proteins
  • Platelet-Derived Growth Factor