The peak of cholelithiasis formation in women concurs with reproductive period and physiological pregnancy serves as a starter of pathological processes in bile-excreting system. The aim of investigation was to reveal the risk-factors of cholelithiasis and cholecystitis during pregnancy. Investigation was a case-control type. A main group consisted of 30 cases. 2-4 pregnant patients in control group were corresponding with each case from main group. Basic significant prognostic factors of cholelithiasis and cholecystitis were determined. They are: fat-rich diet (OR=5.00), feeding irregularity (OR=5.78), visceral obesity (OR=2.67), artificial abortion (OR=3.25); among notable abdominal symptoms during pregnancy are heaviness sensation in right lateral region (OR=406.0), dull ache sensation in right lateral region (OR=196.0) and heartburn sensation (OR=14.50). Thus, revealing the anamnestic risk-factors related with pregnancy and delivery on any stage of pregnancy will be very useful for prevention of cholelithiasis and chronic cholecystitis. The results need to be confirmed by further investigations.