Orofacial pain - a presenting symptom of bisphosphonate associated osteonecrosis of the jaws

Br Dent J. 2007 Jul 28;203(2):91-2. doi: 10.1038/bdj.2007.635.

Abstract

Osteonecrosis of the jaws (ONJ) associated with bisphosphonate therapy is being reported with increasing frequency all over the world. Pain may be the presenting symptom commonly associated with intra-oral bone exposure. The aetiology of this therapeutic complication is still not well understood. Three cases are presented and the management of the condition is discussed.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Anti-Bacterial Agents / therapeutic use
  • Anti-Infective Agents, Local / therapeutic use
  • Bone Density Conservation Agents / adverse effects*
  • Chlorhexidine / therapeutic use
  • Diphosphonates / adverse effects*
  • Facial Pain / etiology*
  • Female
  • Humans
  • Imidazoles / adverse effects
  • Jaw Diseases / chemically induced*
  • Jaw Diseases / complications
  • Jaw Diseases / drug therapy
  • Male
  • Middle Aged
  • Osteonecrosis / chemically induced*
  • Osteonecrosis / complications
  • Osteonecrosis / drug therapy
  • Osteoporosis, Postmenopausal / drug therapy
  • Tetracycline / therapeutic use
  • Zoledronic Acid

Substances

  • Anti-Bacterial Agents
  • Anti-Infective Agents, Local
  • Bone Density Conservation Agents
  • Diphosphonates
  • Imidazoles
  • Zoledronic Acid
  • Tetracycline
  • Chlorhexidine