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, 46 (2), 590-7

Nuclear factor-kappaB and the Hepatic Inflammation-Fibrosis-Cancer Axis


Nuclear factor-kappaB and the Hepatic Inflammation-Fibrosis-Cancer Axis

Ahmed M Elsharkawy et al. Hepatology.


Nuclear factor-kappaB (NF-kappaB) is a transcriptional regulator of genes involved in immunity, inflammatory response, cell fate, and function. Recent attention has focused on the pathophysiological role of NF-kappaB in the diseased liver. In vivo studies using rodent models of liver disease and cell-targeted perturbation of NF-kappaB activity have revealed complex and multicellular functions in hepatic inflammation, fibrosis, and the development of hepatocellular carcinoma - a process we have termed the "inflammation-fibrosis-cancer axis". This review summarizes the current state of knowledge and provides insight into the vast complexity of the hepatic NF-kappaB signaling system, which should provide a rich source of new therapeutic targets.

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