Nuclear factor-kappaB and the hepatic inflammation-fibrosis-cancer axis

Hepatology. 2007 Aug;46(2):590-7. doi: 10.1002/hep.21802.

Abstract

Nuclear factor-kappaB (NF-kappaB) is a transcriptional regulator of genes involved in immunity, inflammatory response, cell fate, and function. Recent attention has focused on the pathophysiological role of NF-kappaB in the diseased liver. In vivo studies using rodent models of liver disease and cell-targeted perturbation of NF-kappaB activity have revealed complex and multicellular functions in hepatic inflammation, fibrosis, and the development of hepatocellular carcinoma - a process we have termed the "inflammation-fibrosis-cancer axis". This review summarizes the current state of knowledge and provides insight into the vast complexity of the hepatic NF-kappaB signaling system, which should provide a rich source of new therapeutic targets.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Carcinoma, Hepatocellular / etiology*
  • Hepatitis / etiology*
  • Humans
  • Liver Cirrhosis / etiology*
  • Liver Neoplasms / etiology*
  • NF-kappa B / physiology*
  • Signal Transduction
  • Toll-Like Receptors / physiology

Substances

  • NF-kappa B
  • Toll-Like Receptors