Immunosenescence: deficits in adaptive immunity in the elderly

Tissue Antigens. 2007 Sep;70(3):179-89. doi: 10.1111/j.1399-0039.2007.00891.x.


Aging is associated clinically with increases in the frequency and severity of infectious diseases and an increased incidence of cancer, chronic inflammatory disorders and autoimmunity. These age-associated immune dysfunctions are the consequence of declines in both the generation of new naïve T and B lymphocytes and the functional competence of memory populations. These alterations collectively are termed immunosenescence.

Publication types

  • Review

MeSH terms

  • Aged
  • Aging / immunology*
  • Animals
  • Humans
  • Immunity, Active / immunology*
  • Immunologic Deficiency Syndromes / immunology*