Inflammation and its role in neuroprotection, axonal regeneration and functional recovery after spinal cord injury

Exp Neurol. 2008 Feb;209(2):378-88. doi: 10.1016/j.expneurol.2007.06.009. Epub 2007 Jun 30.


Trauma to the central nervous system (CNS) triggers intraparenchymal inflammation and activation of systemic immunity with the capacity to exacerbate neuropathology and stimulate mechanisms of tissue repair. Despite our incomplete understanding of the mechanisms that control these divergent functions, immune-based therapies are becoming a therapeutic focus. This review will address the complexities and controversies of post-traumatic neuroinflammation, particularly in spinal cord. In addition, current therapies designed to target neuroinflammatory cascades will be discussed.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Animals
  • Axons / physiology*
  • Humans
  • Inflammation / physiopathology*
  • Recovery of Function / physiology*
  • Regeneration / physiology*
  • Spinal Cord Injuries* / metabolism
  • Spinal Cord Injuries* / pathology
  • Spinal Cord Injuries* / physiopathology