Novel clusters of highly expressed genes accompany genomic amplification in breast cancers

FEBS Lett. 2007 Aug 21;581(21):3909-14. doi: 10.1016/j.febslet.2007.07.016. Epub 2007 Jul 23.

Abstract

Breast cancer is the most common cancer in women worldwide. To identify novel amplicons involved in the mammary carcinogenesis, we constructed gene expression maps of chromosomes in 35 human breast cancer cell lines and extracted six candidate amplicons containing highly expressed gene clusters on chromosomes 8, 17, and X. We also confirmed the presence of the identified amplicons in clinical specimens by Southern blot analysis. Highly expressed genes identified in the amplicons will contribute to the characterization of breast cancer phenotypes, thereby providing novel targets for anticancer therapies.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Breast Neoplasms / genetics
  • Breast Neoplasms / metabolism*
  • Breast Neoplasms / therapy
  • Cell Line, Tumor
  • Chromosomes, Human / genetics
  • Chromosomes, Human / metabolism*
  • Female
  • Gene Expression Profiling
  • Gene Expression Regulation, Neoplastic*
  • Humans
  • Multigene Family*
  • Neoplasm Proteins / biosynthesis*
  • Neoplasm Proteins / genetics
  • Oligonucleotide Array Sequence Analysis
  • Phenotype

Substances

  • Neoplasm Proteins