Specifying positional information in the embryo: looking beyond morphogens

Cell. 2007 Jul 27;130(2):205-9. doi: 10.1016/j.cell.2007.06.038.


Concentration gradients of small diffusible molecules called morphogens are key regulators of development, specifying position during pattern formation in the embryo. It is now becoming clear that additional or alternative mechanisms involving interactions among cells are also crucial for positional specification.

MeSH terms

  • Animals
  • Body Patterning*
  • Drosophila melanogaster / embryology*
  • Embryo, Nonmammalian / metabolism*