Cellular senescence in cancer and aging

Cell. 2007 Jul 27;130(2):223-33. doi: 10.1016/j.cell.2007.07.003.


Cellular senescence, a state of irreversible growth arrest, can be triggered by multiple mechanisms including telomere shortening, the epigenetic derepression of the INK4a/ARF locus, and DNA damage. Together these mechanisms limit excessive or aberrant cellular proliferation, and so the state of senescence protects against the development of cancer. Recent evidence suggests that cellular senescence also may be involved in aging.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Aging / pathology*
  • Animals
  • Cellular Senescence*
  • Cyclin-Dependent Kinase Inhibitor p16 / metabolism
  • DNA Damage
  • Humans
  • Neoplasms / pathology*
  • Telomere / metabolism


  • Cyclin-Dependent Kinase Inhibitor p16