Refining the predictive pursuit endophenotype in schizophrenia

Biol Psychiatry. 2008 Mar 1;63(5):458-64. doi: 10.1016/j.biopsych.2007.06.004. Epub 2007 Jul 30.


Background: To utilize fully a schizophrenia endophenotype in gene search and subsequent neurobiological studies, it is critical that the precise underlying physiologic deficit is identified. Abnormality in smooth pursuit eye movements is one of the endophenotypes of schizophrenia. The precise nature of the abnormality is unknown. Previous work has shown a reduced predictive pursuit response to a briefly masked (i.e., invisible) moving object in schizophrenia. However, the overt awareness of target removal can confound the measurement.

Methods: This study employed a novel method that covertly stabilized the moving target image onto the fovea. The foveal stabilization was implemented after the target on a monitor had oscillated at least for one cycle and near the change of direction when the eye velocity momentarily reached zero. Thus, the subsequent pursuit eye movements were completely predictive and internally driven. Eye velocity during this foveally stabilized smooth pursuit was compared among schizophrenia patients (n = 45), their unaffected first-degree relatives (n = 42), and healthy comparison subjects (n = 22).

Results: Schizophrenia patients and their unaffected relatives performed similarly and both had substantially reduced predictive pursuit acceleration and velocity under the foveally stabilized condition.

Conclusions: These findings show that inability to maintain internal representation of the target motion or integration of such information into a predictive response may be the specific brain deficit indexed by the smooth pursuit endophenotype in schizophrenia. Similar performance between patients and unaffected relatives suggests that the refined predictive pursuit measure may index a less complex genetic origin of the eye-tracking deficits in schizophrenia families.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Attention
  • Awareness
  • Brief Psychiatric Rating Scale
  • Female
  • Genetic Testing
  • Humans
  • Male
  • Middle Aged
  • Motion Perception
  • Perceptual Masking
  • Phenotype*
  • Pursuit, Smooth / genetics*
  • Schizophrenia / diagnosis
  • Schizophrenia / genetics*
  • Schizophrenic Psychology
  • Schizotypal Personality Disorder / diagnosis
  • Schizotypal Personality Disorder / genetics
  • Schizotypal Personality Disorder / psychology