Metabotropic glutamate receptors: phosphorylation and receptor signaling

J Neurosci Res. 2008 Jan;86(1):1-10. doi: 10.1002/jnr.21437.


Metabotropic glutamate receptors (mGluRs) play important roles in neurotransmission, neuronal development, synaptic plasticity, and neurological disorders. Recent studies have revealed a sophisticated interplay between mGluRs and protein kinases: activation of mGluRs regulates the activity of a number of kinases, and direct phosphorylation of mGluRs affects receptor signaling, trafficking, and desensitization. Here we review the emerging literature on mGluR phosphorylation, signaling, and synaptic function.

Publication types

  • Research Support, N.I.H., Intramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Models, Biological
  • Phosphorylation
  • Receptors, Metabotropic Glutamate / metabolism
  • Receptors, Metabotropic Glutamate / physiology*
  • Signal Transduction / physiology*
  • Synapses / physiology*


  • Receptors, Metabotropic Glutamate