Serum IgA class anti-IgA antibody in IgA nephropathy

Nephron. 1991;59(4):552-60. doi: 10.1159/000186643.

Abstract

IgA class anti-IgA antibody was sought by an immunoabsorbent technique in sera from patients with IgA nephropathy (IgA-N, n = 62), other forms of primary glomerulonephritis (PGN, n = 41), seropositive rheumatoid arthritis (RF-positive, n = 18) and normal controls (c, n = 50). IgA-N (31%) and RF-positive (56%) patients showed a significant increase in IgA anti-IgA antibody levels. The subclass of IgA anti-IgA antibody was predominantly IgA1 in both IgA-N and RF-positive patients. Size analysis revealed the dimer/monomer ratio to be significantly increased in IgA-N patients compared with that of RF-positive patients (p = 0.03). These results indicate the possible existence of the dimeric form of IgA class anti-IgA antibody in the circulation of IgA-N patients.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antibodies, Anti-Idiotypic / blood*
  • Antibodies, Anti-Idiotypic / chemistry
  • Antibodies, Anti-Idiotypic / classification
  • Antibody Specificity
  • Glomerulonephritis, IGA / immunology*
  • Humans
  • Immunoglobulin A / chemistry
  • Immunoglobulin A / classification
  • Immunoglobulin A / metabolism*
  • Immunoglobulin G
  • Immunoglobulin M
  • Rheumatoid Factor / blood

Substances

  • Antibodies, Anti-Idiotypic
  • Immunoglobulin A
  • Immunoglobulin G
  • Immunoglobulin M
  • Rheumatoid Factor