In this study we investigated in a Simon-like task whether task-irrelevant spatial information, delivered by centrally presented patterns, interfered with response selection in the same way as laterally presented stimuli. Second, we asked whether such interference was equal for different kinds of stimuli. Participants were required to respond to the colour of two framed squares, two arrows, or two schematic eyes by pressing one of two lateralized response keys. The results consistently show that the Simon effect occurs independently of the nature of the stimulus, as classically reported for lateralized stimuli. Response times were influenced by the direction and frame-relative position of the stimuli, being faster for responses corresponding to the direction indicated by the stimuli than for noncorresponding responses regardless of stimulus types. Contrary to findings with lateralized nondirectional stimuli, such an effect increased with increasing RTs indicating that for centrally presented patterns the extraction of spatial information is time consuming.