Drug-induced thrombocytopenia

Hematol Oncol Clin North Am. 2007 Aug;21(4):685-96, vi. doi: 10.1016/j.hoc.2007.06.005.


Drug-induced thrombocytopenia (DIT) is a relatively common clinical disorder. It is imperative to provide rapid identification and removal of the offending agent before clinically significant bleeding or, in the case of heparin, thrombosis occurs. DIT can be distinguished from idiopathic thrombocytopenic purpura, a bleeding disorder caused by thrombocytopenia not associated with a systemic disease, based on the history of drug ingestion or injection and laboratory findings. DIT disorders can be a consequence of decreased platelet production (bone marrow suppression) or accelerated platelet destruction (especially immune-mediated destruction).

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Antibodies / blood
  • Antibody Formation
  • Drug-Related Side Effects and Adverse Reactions
  • Haptens / adverse effects
  • Haptens / immunology
  • Humans
  • Thrombocytopenia / chemically induced*
  • Thrombocytopenia / diagnosis
  • Thrombocytopenia / etiology


  • Antibodies
  • Haptens