Effect of Usuhiratake (Pleurotus pulmonarius) on sneezing and nasal rubbing in BALB/c mice

Biol Pharm Bull. 2007 Aug;30(8):1557-60. doi: 10.1248/bpb.30.1557.


The anti-rhinitis properties of Pleurotus pulmonarius were investigated in BALB/c mice. A single administration of Pleurotus Pulmonarius caused no significant effect on antigen-induced nasal rubbing and sneezing at a dose of 500 mg/kg, but a significant inhibition was observed after 2 weeks of repeated treatment at this dose, and at a dose of 200 mg/kg, it also caused a significant inhibition after repeated administration for 4 weeks. Pleurotus pulmonarius showed no significant inhibitory effect on the production of IgE. In addition, Pleurotus pulmonarius caused no inhibition of histamine-induced nasal rubbing and sneezing at a dose of 500 mg/kg, but in vitro study, it inhibited histamine release from rat mast cells induced by compound 48/80 at the soluble supernatant solution of 30 and 100 microg/ml of Pleurotus pulmonarius suspended in PBS. These results demonstrated that Pleurotus pulmonarius may be effective in the relief of symptoms of allergic rhinitis through inhibition of histamine release.

MeSH terms

  • Animals
  • Anti-Allergic Agents*
  • Behavior, Animal / drug effects
  • Female
  • Histamine / pharmacology
  • Histamine Release / drug effects
  • Immunoglobulin E / metabolism
  • Indicators and Reagents
  • Mast Cells / drug effects
  • Mast Cells / metabolism
  • Mice
  • Mice, Inbred BALB C
  • Pleurotus / chemistry*
  • Rhinitis / drug therapy*
  • Rhinitis / psychology
  • Sneezing / drug effects*
  • p-Methoxy-N-methylphenethylamine / pharmacology


  • Anti-Allergic Agents
  • Indicators and Reagents
  • Immunoglobulin E
  • p-Methoxy-N-methylphenethylamine
  • Histamine