Antifungal potential of disulfiram

Nihon Ishinkin Gakkai Zasshi. 2007;48(3):109-13. doi: 10.3314/jjmm.48.109.

Abstract

Disulfiram, an alcohol antagonistic drug has been on the market since 1949 with 80% bioavailability and an established safety profile. Recently it has been reported as a P-glycoprotein efflux pump modulator. Herein we report its antifungal potential. The MIC50 and MIC90 of disulfiram for yeast isolates is 4 and 8 microg/ml, respectively, and the MIC range is 1-16 micro g/ml for both fluconazole sensitive and resistant strains. Interestingly, disulfiram also showed fungicidal activity on Aspergillus spp. with MIC50 and MIC90 of 2 and 8 microg/ml, respectively.

Publication types

  • Review

MeSH terms

  • Antifungal Agents / pharmacology*
  • Aspergillus / drug effects
  • Disulfiram / pharmacology*
  • Microbial Sensitivity Tests
  • Yeasts / drug effects

Substances

  • Antifungal Agents
  • Disulfiram