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, 19 (25), 7043-7

The ste4+ Gene, Essential for Sexual Differentiation of Schizosaccharomyces Pombe, Encodes a Protein With a Leucine Zipper Motif

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The ste4+ Gene, Essential for Sexual Differentiation of Schizosaccharomyces Pombe, Encodes a Protein With a Leucine Zipper Motif

N Okazaki et al. Nucleic Acids Res.

Abstract

Ste4- mutants of Schizosaccharomyces pombe are unable to undergo both mating and meiosis. We have cloned the ste4+ gene and its cDNA. The gene encodes a 264 amino acid protein with a typical leucine zipper motif homologous with the jun family. However, unlike the jun family, this protein does not have a typical basic region that precedes the leucine zipper. The transcription of this gene absolutely depends on the ste11+ gene and increases several fold upon nitrogen starvation, a general signal for sexual differentiation. Whereas ste4+ is essential for mating and meiosis, its overexpression inhibits these processes.

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