Abstract
The actions of intravenous anaesthetics on 5-HT(3AB) receptors have not been studied. Using oocyte electrophysiology, the effects of etomidate, propofol, and pentobarbital on human 5-HT(3A) and 5-HT(3AB) receptors were studied and compared. Inhibition of peak currents by all three compounds in both receptor subtypes was anaesthetic concentration-dependant and non-competitive. Because the half-maximal inhibitory concentrations for etomidate, propofol and pentobarbital in 5-HT(3A) and 5-HT(3AB) receptors were all above their respective anaesthetic concentrations, the results of our study suggest that neither 5-HT(3) receptor subtype contributes to the anaesthetic actions of etomidate, propofol or pentobarbital.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Dose-Response Relationship, Drug
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Electrophysiology / methods
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Etomidate / pharmacology*
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Female
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Humans
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Hypnotics and Sedatives / pharmacology
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Membrane Potentials / drug effects
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Microinjections
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Oocytes / drug effects
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Oocytes / metabolism
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Oocytes / physiology
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Pentobarbital / pharmacology*
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Propofol / pharmacology*
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Protein Isoforms / genetics
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Protein Isoforms / physiology
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RNA / administration & dosage
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RNA / genetics
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Receptors, Serotonin, 5-HT3 / genetics
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Receptors, Serotonin, 5-HT3 / physiology*
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Xenopus laevis
Substances
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Hypnotics and Sedatives
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Protein Isoforms
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Receptors, Serotonin, 5-HT3
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RNA
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Pentobarbital
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Propofol
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Etomidate