[Increasing the radioprotective therapeutic efficacy of typhoid vaccine using sexta-anatoxin in combination with the antimetabolite methotrexate]

Iu B Deshevoĭ; K S Martirosov; I E Andrianova

[Increasing the radioprotective therapeutic efficacy of typhoid vaccine using sexta-anatoxin in combination with the antimetabolite methotrexate]

Radiobiologiia. 1991 Nov-Dec;31(6):853-5.

[Article in Russian]

Authors

Iu B Deshevoĭ, K S Martirosov, I E Andrianova

PMID: 1767016

Abstract

A typhoid vaccine with sexta-anatoxin delivered to mice 4.5-5 h after gamma-irradiation has a pronounced therapeutic effect: survival rate is 42% with radiation dose of 8.2 Gy (LD85/30) and 19% with radiation dose of 8.7 Gy (LD95/30). The vaccine of 2.5 and 5 mg/kg combined with methotrexate has a more pronounced therapeutic effect increasing the survival rate up to 65% (LD85/30) and up to 35-40% (LD95/30).

Publication types

English Abstract

MeSH terms

Animals
Drug Therapy, Combination
Male
Methotrexate / therapeutic use*
Mice
Radiation Injuries, Experimental / prevention & control*
Radiation-Protective Agents / therapeutic use*
Toxoids / therapeutic use*
Typhoid-Paratyphoid Vaccines / therapeutic use*

Substances

Radiation-Protective Agents
Toxoids
Typhoid-Paratyphoid Vaccines
Methotrexate