A 42-year-old man was hospitalized because of an infectious giant bulla. The infected giant bulla did not improve by the administration of antibiotics. Some infectious bullae were considered to be difficult to allow for simple cutaneous drainage, so endoscopic drainage was performed to remove the infection. Our experience with endoscopic abscess drainage is excellent in patients in whom conventional therapy fails. We consider the endoscopic drainage an alternative to percutaneous drainage in patients who have an infectious bulla.