The targets of CAPRI rounds 6-12

Proteins. 2007 Dec 1;69(4):699-703. doi: 10.1002/prot.21689.

Abstract

Six protein-protein complexes and two homodimeric proteins involved in a variety of biological processes were offered as targets to CAPRI by crystallographers in Rounds 6-12. CAPRI predictor groups had to predict their structure by docking the free proteins, which they did with a degree of success that depended largely on the amplitude of the conformation changes. In one case at least, the prediction pointed to alternative possibilities of interactions in the crystal of a complex, showing that docking methods have value even when there is an experimental structure.

MeSH terms

  • Algorithms
  • Computational Biology / methods*
  • Computer Simulation*
  • Crystallography, X-Ray / methods
  • Databases, Protein
  • Dimerization
  • Humans
  • Molecular Conformation
  • Protein Binding
  • Protein Conformation
  • Protein Interaction Mapping*
  • Proteins / chemistry*
  • Proteomics / methods*
  • Software

Substances

  • Proteins