Demineralized bone matrix composite grafting for posterolateral spinal fusion

Orthopedics. 2007 Jul;30(7):567-70. doi: 10.3928/01477447-20070701-06.


In a prospective series, the 24-month fusion status was evaluated radiographically among patients undergoing instrumented posterolateral lumbosacral spinal fusion. Seventy-three patients had a diagnosis of degenerative disk disease or degenerative spondylolisthesis and had supplemental bone grafting with demineralized bone matrix (DBM) putty (Grafton DBM; Osteotech, Eatontown, NJ) enriched with aspirated bone marrow (DBM bone marrow), DBM putty combined with iliac crest autograft (DBM autograft), or autograft. Overall, approximately 63% (12 of 19) of DBM bone marrow, 70% (19 of 27) of DBM autograft, and 67% (18 of 27) of autograft patients were fused at 24 months (P = .875). These findings suggest that both DBM composites offer similar performance to autograft in posterolateral spinal fusion.

Publication types

  • Multicenter Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Bone Demineralization Technique*
  • Bone Marrow Transplantation
  • Bone Substitutes / therapeutic use*
  • Case-Control Studies
  • Female
  • Follow-Up Studies
  • Humans
  • Ilium / transplantation
  • Low Back Pain / surgery
  • Male
  • Middle Aged
  • Pain, Intractable / surgery
  • Prospective Studies
  • Spinal Fusion / methods*
  • Transplantation, Autologous
  • Treatment Outcome


  • Bone Substitutes