Post-challenge glucose predicts coronary atherosclerotic progression in non-diabetic, post-menopausal women

Diabet Med. 2007 Oct;24(10):1156-9. doi: 10.1111/j.1464-5491.2007.02222.x. Epub 2007 Aug 2.

Abstract

Aims: We sought to determine whether fasting or post-challenge glucose were associated with progression of coronary atherosclerosis in non-diabetic women.

Methods: We performed a post-hoc analysis of 132 non-diabetic women who underwent 75-g oral glucose tolerance testing. The primary outcome of interest was progression of atherosclerosis determined by baseline and follow-up coronary angiography, a mean of 3.1 +/- 0.9 years apart. We analysed the association of change in minimal vessel diameter (DeltaMD) by quartile of fasting and post-challenge glucose using mixed models that included adjustment for age, systolic blood pressure, total : high-density lipoprotein cholesterol ratio, current smoking, lipid-lowering and anti-hypertensive medication use and other covariates.

Results: At baseline, participants had a mean age of 65.7 +/- 6.7 years and a mean body mass index of 27.9 +/- 8.5 kg/m(2). Although there were no significant differences in atherosclerotic progression by fasting glucose category (P for trend across quartiles = 0.99), there was a significant inverse association between post-challenge glucose and DeltaMD (in mm) (Q1 : 0.01 +/- 0.03; Q2 : 0.08 +/- 0.03; Q3 : 0.13 +/- 0.03; Q4 : 0.11 +/- 0.03; P for trend = 0.02).

Conclusions: In post-menopausal women without diabetes, post-challenge glucose predicts angiographic disease progression. These findings suggest that even modest post-challenge hyperglycaemia influences the pathogenesis of atherosclerotic progression.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Aged
  • Atherosclerosis / diagnosis
  • Biomarkers / metabolism
  • Blood Glucose / analysis
  • Blood Glucose / metabolism*
  • Cohort Studies
  • Coronary Angiography / methods*
  • Disease Progression
  • Female
  • Glucose Tolerance Test / methods*
  • Humans
  • Postmenopause
  • Predictive Value of Tests
  • Treatment Outcome

Substances

  • Biomarkers
  • Blood Glucose