The nonthyroidal illness syndrome

Endocrinol Metab Clin North Am. 2007 Sep;36(3):657-72, vi. doi: 10.1016/j.ecl.2007.04.007.


This article briefly summarizes thyroid function alterations generally seen in the euthyroid sick syndrome, provides an overview of specific thyroidal adaptations during several clinical conditions and secondary to specific pharmacologic agents, and discusses the current controversy in thyroid hormone treatment of nonthyroidal illness.

Publication types

  • Review

MeSH terms

  • Euthyroid Sick Syndromes / diagnosis
  • Euthyroid Sick Syndromes / drug therapy*
  • Euthyroid Sick Syndromes / etiology*
  • Fasting
  • Heart Diseases / complications
  • Humans
  • Infections / complications
  • Kidney Diseases / complications
  • Liver Diseases / complications
  • Starvation / complications
  • Thyroid Hormones / blood*
  • Thyroid Hormones / therapeutic use*


  • Thyroid Hormones