The influence of alpha-ketoglutarate (AKG) on mineralisation, mechanical and structural properties of ulna in turkey under conditions of osteotomy and denervation

Ortop Traumatol Rehabil. 2003 Oct 30;5(5):666-72.


Background. Mechanical endurance of bones to acting forces is a result of geometrical properties, mineralisation and quality of the material they are built. Bone mineral density decrease influences lower bone mechanical endurance and its higher susceptibility on fractures. Among many factors that condition proper growth, development and repair processes of skeletal system, nervous system plays very important role in processes of bone metabolism regulation and its homeostasis maintenance. Bone fractures occurrence as a result of osteopenia and its fractures connected with peripheral nervous system injury require investigations of new and effective treatments that would guarantee correct repair processes of bone tissue and its physiological function maintenance. Material and methods. All investigation was performed on 16 turkeys divided into two groups. Right ulnae were subjected to denervation, osteotomy and osteosynthesis. The first group of turkeys served as control, the second group were administered alpha-ketoglutarate (AKG) directly to crop at the dosage of 0.4g/kg b.w./day by 14 weeks, starting on the next day after surgery. After finishing breeding part of experiment, the influence of AKG on mineralisation, structural and mechanical properties of denervated and osteotomied ulna was investigated. Results. Performed investigations on ulna after its osteotomy and denervation elucidated different callus formation in turkeys belong to control group and receiving AKG. The positive influence of alpha-ketoglutarate administration on morphology, mineralisation and mechanical properties of experimentally osteotomied and denervated ulna was stated.Conclusions. Obtained results prove anabolic effect of alpha-ketoglutarate on bone tissue, after its administration via digestive tract. Considering increased mineralisation, higher volumetric cortical bone density and increased trabecular bone density, AKG can be utilised as a factor in prevention of osteopenia and osteoporosis. Achieved results indicate possibility of existence connection by AKG between digestive system and skeletal system.