The role of dendritic cells in the immunopathogenesis of psoriasis

Arch Dermatol Res. 2007 Oct;299(8):359-66. doi: 10.1007/s00403-007-0775-4. Epub 2007 Aug 7.


Psoriasis vulgaris is a chronic inflammatory skin disease that is marked by a complex interplay of dendritic cells (DCs), T-cells, cytokines, and downstream transcription factors as part of a self-sustaining type 1 cytokine network. As integral players of the immune system, DCs represent antigen-presenting cells that are crucial for efficient activation of T-cells and B-cells. DCs have also been linked to distinct chronic inflammatory conditions, including psoriasis. In the setting of psoriasis therapy, DC/T cell interactions serve as a potential target for biologic response modifiers. Here we describe the major DC subsets as well as the immunologic involvement of DCs within the context of psoriatic lesions.

Publication types

  • Review

MeSH terms

  • Cell Communication / immunology
  • Humans
  • Langerhans Cells / immunology*
  • Langerhans Cells / pathology*
  • Psoriasis / immunology*
  • Psoriasis / pathology*
  • T-Lymphocytes / immunology
  • T-Lymphocytes / pathology