Loss of pregnancy-associated plasma protein A extends lifespan in mice

Aging Cell. 2007 Oct;6(5):727-9. doi: 10.1111/j.1474-9726.2007.00328.x. Epub 2007 Aug 6.

Abstract

Genetic deletion in mice of pregnancy-associated plasma protein A (PAPP-A), a recently identified metalloproteinase in the insulin-like growth factor system, extends by 30-40% both mean and maximum lifespan with no reduction in food intake or secondary endocrine abnormalities. Furthermore, these mice have markedly reduced incidence of spontaneous tumors. The findings implicate PAPP-A as a critical regulator of lifespan and age-related diseases, and suggest PAPP-A as a possible target to promote longevity.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Female
  • Longevity / physiology*
  • Mice
  • Mice, Mutant Strains
  • Pregnancy-Associated Plasma Protein-A / metabolism*

Substances

  • Pregnancy-Associated Plasma Protein-A