Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
, 40 (9), 1664-8

The p75 Neurotrophin Receptor

Affiliations
Review

The p75 Neurotrophin Receptor

Clare K Underwood et al. Int J Biochem Cell Biol.

Abstract

The pan neurotrophin receptor (p75(NTR)) is best known for mediating neural cell death during development as well as in the adult following injury, the latter making it a target for the treatment of neurodegenerative disease. Although p75(NTR) has been studied for over 30 years, a number of recent discoveries have changed our understanding of its regulation. Here we provide a brief overview of the p75(NTR) protein, its post-translational modifications, and the phenotype of p75(NTR)-deficient mice as a starting point for researchers unfamiliar with this complex receptor. The accepted mechanisms underlying the ability of p75(NTR) to regulate cell death as well as a number of other neural functions, most notably neuronal differentiation, neurite outgrowth and synaptic plasticity, are also summarised.

Similar articles

See all similar articles

Cited by 38 articles

See all "Cited by" articles

Substances

LinkOut - more resources

Feedback