Long-term management of prolactinomas

J Clin Endocrinol Metab. 2007 Aug;92(8):2861-5. doi: 10.1210/jc.2007-0836.


Prolactinomas are a frequent cause of gonadal dysfunction and infertility, especially in young women. The regulation of prolactin secretion and the efficacy of dopamine agonists in the therapy of prolactinomas are well established. The current challenges in management of prolactinomas are related to follow-up after successful therapy. Issues and questions to be addressed in this approach to long-term management of prolactinomas include the frequency of radiographic monitoring, effect of pregnancy and menopause, safety of estrogen in women taking oral contraceptives, and the potential for discontinuation of dopamine agonist therapy.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Adult
  • Amenorrhea / etiology
  • Contraceptives, Oral, Hormonal / therapeutic use
  • Dopamine Agonists / therapeutic use
  • Estrogens / pharmacology
  • Female
  • Galactorrhea / etiology
  • Humans
  • Magnetic Resonance Imaging
  • Male
  • Menopause / physiology
  • Middle Aged
  • Pituitary Neoplasms / complications
  • Pituitary Neoplasms / pathology
  • Pituitary Neoplasms / therapy*
  • Pregnancy
  • Prolactinoma / complications
  • Prolactinoma / pathology
  • Prolactinoma / therapy*


  • Contraceptives, Oral, Hormonal
  • Dopamine Agonists
  • Estrogens