Yttrium tetragonal Zirconia polycrystals (Y-TZP) based systems are the more recent addition in to the high-strength all-ceramic systems that are used for crowns and fixed partial dentures. CAD/CAM produced Y-TZP based systems are being used and are said to be in demand in the aesthetic zone and in stress bearing regions as well. This systematic overview covers results of recent scientific studies and the specific clinical guidelines for its usage. The following paper also offers our clinical experience with Cercon Y-TZP based material (DeguDent, A Dentsply Internatiol Co, Rodenbacher, Hanu.) in long span six unit's fixed partial denture (FPD) in an aesthetic zone.